The Santa Cruz Museum takes its name from the building that serves as its headquarters, the old Santa Cruz Hospital, founded by Cardinal Pedro González de Mendoza (1428-1495) as a general hospital and for the care of foundling children. The building was built in the first decades of the sixteenth century, after the death of its founder, and is one of the master architectural works of the Spanish Renaissance. It has a Greek cross plan with two floors, a large central transept open to both floors and a total of eight bays, plus another room above the hall, all covered with wooden roofs. It also has two cloister patios arranged between his arms. In his design and execution, such outstanding figures worked as Antón and Enrique Egas, famous Toledo architects of Flemish origin, and the master Alonso de Covarrubias. Its magnificent cover, dedicated to the devotion of the Holy Cross, the main cloister and the splendid staircase of Covarrubias, in the main courtyard, justify the visit to this Museum.